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| scavenger receptor ： ウィキペディア英語版 |
scavenger receptor
Scavenger receptors are a group of receptors that recognize modified low-density lipoprotein (LDL) by oxidation or acetylation. This naming is based on a function of cleaning (scavenging): Scavenger receptors widely recognize and take up macromolecules that have a negative charge, like modified LDL.
== Function ==
It is thought that scavenger receptors participate in the removal of many foreign substances and waste materials in the living body by extensive ligand specificity and a variety of receptor molecules.
In atherosclerotic lesions, macrophages that express scavenger receptors on their plasma membrane take up the oxidized LDL deposited in the blood vessel wall aggressively, and develop into foam cells. Likewise they secrete various inflammatory cytokines and accelerate the development of atherosclerosis.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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